The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates.

Autor: Poty, S., Membreno, R., Glaser, J. M., Ragupathi, A., Scholz, W. W., Zeglis, B. M., Lewis, J. S.
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Zdroj: Chemical Communications; 3/14/2018, Vol. 54 Issue 21, p2599-2602, 4p
Abstrakt: The inverse electron-demand Diels–Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index