| Autor: |
Mellanen, Llisa, Sorsa, Timo, Lähdevirta, Juhani, Helenlus, Mila, Karl, Kirsti, Meurman, Jukka H., Mellanen, L, Sorsa, T, Lähdevirta, J, Helenius, M, Kari, K, Meurman, J H |
| Předmět: |
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| Zdroj: |
Journal of Oral Pathology & Medicine; Oct2001, Vol. 30 Issue 9, p553-559, 7p |
| Abstrakt: |
HIV infection reduces oral defensive mechanisms and may affect mucosal integrity. Differences in salivary protein concentrations and periodontopathogenic bacteria were studied in 56 HIV-infected patients with respect to their disease phase. Thirty-three patients were followed up for 2 years. Fifty-three healthy subjects of corresponding age and sex were studied as controls. At base- line, salivary albumin, total protein, lgA, and lgM levels were significantly higher (P<0.05'-0.0001) in all phases of HIV infection. except the asyrnptomatic (ASX) phase, when compared with the control group. lgG levels were significantly increased in all phases except the ASX phase (P<0.05). After 2 years, salivary total protein, lgG, and 1gM levels were still higher (P<0..05- 0.005) in all HIV phases when compared with the control group (P<0.05-0.005}. The albumin level was significantly higher in the ASX phase (P<0.005) and in the AIDS-related complex phase (ARC) (PC 0.05)1 while the increase in IgA level was significant only in the ARC phase (P<0.005). Periodontopathogenic bacteria analyzed by PCR were detected both in the patients and the non-infected, but a statistically significant difference in the carriage percentage between the follow-up lymphadenopathy syndrome phase (LAS) and the control group was found only in Porphyromorias gingivalis (PcO.05) and Bacteroides forsythus (P< 0.0001). Thus. F-IIV infection appeared to cause a significant increase in the studied salivary proteins, suggesting leakage of serum components into the mouth. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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