| Autor: |
van der Hage, J. A., van den Broek, L. J. C. M., Legrand, C., Clahsen, P. C., Bosch, C. J. A., Robanus-Maandag, E. C., van de Velde, C. J. H., van de Vijver, M. J. |
| Předmět: |
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| Zdroj: |
British Journal of Cancer; 4/19/2004, Vol. 90 Issue 8, p1543-1550, 8p, 1 Black and White Photograph, 7 Charts |
| Abstrakt: |
The RPS6KB1 gene is amplified and overexpressed in approximately 10% of breast carcinomas and has been found associated with poor prognosis. We studied the prognostic significance of P70 S6 kinase protein (PS6K) overexpression in a series of 452 node-negative premenopausal early-stage breast cancer patients (median follow-up: 10.8 years). Immunohistochemistry was used to assess PS6K expression in the primary tumour, which had previously been analysed for a panel of established prognostic factors in breast cancer. In a univariate analysis, PS6K overexpression was associated with worse distant disease-free survival as well as impaired locoregional control (HR 1.80, P 0.025 and HR 2.50, P 0.006, respectively). In a multivariate analysis including other prognostic factors, PS6K overexpression remained an independent predictor for poor locoregional control (RR 2.67, P 0.003). To our knowledge, P70 S6 kinase protein is the first oncogenic marker that has prognostic impact on locoregional control and therefore may have clinical implications in determining the local treatment strategy in early-stage breast cancer patients.British Journal of Cancer (2004) 90, 1543-1550. doi:10.1038/sj.bjc.6601741 www.bjcancer.com Published online 30 March 2004 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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