Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma.

Autor: Moron, Roberson A., Jacob, Carlos Eduardo, Bresciani, Claudio José Caldas, Simões, Kleber, Alves, Venâncio Avancini Ferreira, Irya, Kyoshi, Gama-Rodrigues, Joaquim, Cecconello, Ivan, Longatto-Filho, Adhemar, Zilberstein, Bruno
Předmět:
Zdroj: Molecular & Clinical Oncology; Mar2018, Vol. 8 Issue 3, p477-482, 6p
Abstrakt: The aim of the present study was to determine the clinical significance of p53 and p21ras p21wafl, p27kip1 and p16ink4a expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras, p53, p21waf1/cip1, p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21ras was positive in 85.3, 86 and 96.8%, respectively. Positivity for p16ink4a was detected in 46.3, 91.1 and 86% of the cases, respectively, whereas p27kip1 was positive in 60, 94.7 and 95.3%, and p21wafl/cip1 was positive in 32.4, 72.7 and 71.4% of the cases, respectively. All the tumors were positive for p53. Tumors with lymph node invasion presented with overexpression (+4) of p53 in 47% of the cases vs. 17% of patients who did not have lymph node involvement. Therefore, higher expression of p53, p21ras and p21wafl/cip1 in the tumor exhibited a statistically significant association with lymph node involvement. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje