| Autor: |
van Dinther, Dieke, Veninga, Henrike, Iborra, Salvador, Borg, Ellen G. F., Hoogterp, Leoni, Olesek, Katarzyna, Beijer, Marieke R., Schetters, Sjoerd T. T., Kalay, Hakan, Garcia-Vallejo, Juan J., Franken, Kees L., Cham, Lamin B., Lang, Karl S., van Kooyk, Yvette, Sancho, David, Crocker, Paul R., den Haan, Joke M. M. |
| Zdroj: |
Cell Reports; 2/6/2018, Vol. 22 Issue 6, p1484-1495, 12p |
| Abstrakt: |
Splenic CD169+ macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8+ T cell responses by antigens (Ags) bound by CD169+ macrophages. Upon Ag targeting to CD169+ macrophages, we show that BATF3-dependent CD8α+ dendritic cells (DCs) are crucial for DNGR-1-mediated cross-priming of CD8+ T cell responses. In addition, we demonstrate that CD169, a sialic acid binding lectin involved in cell-cell contact, preferentially binds to CD8α+ DCs and that Ag transfer to CD8α+ DCs and subsequent T cell activation is dependent on the sialic acidbinding capacity of CD169. Finally, functional CD169 mediates optimal CD8+ T cell responses to modified vaccinia Ankara virus infection. Together, these data indicate that the collaboration of CD169+ macrophages and CD8α+ DCs for the initiation of effective CD8+ T cell responses is facilitated by binding of CD169 to sialic acid containing ligands on CD8α+ DCs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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