| Autor: |
Schneider, Ralf F., Franchini, Paolo, Meyer, Axel, Hyuk Je Lee, Manousaki, Tereza, Ji Hyoun Kang, Lein, Etienne |
| Předmět: |
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| Zdroj: |
Genome Biology & Evolution; Nov2017, Vol. 9 Issue 11, p3122-3136, 15p |
| Abstrakt: |
Lateralized behavior ("handedness") is unusual, but consistently found across diverse animal lineages, including humans. It is thought to reflect brain anatomical and/or functional asymmetries, but its neuro-molecular mechanisms remain largely unknown. Lake Tanganyika scale-eating cichlid fish, Perissodus microlepis show pronounced asymmetry in their jaw morphology as well as handedness in feedingbehavior--bitingscales preferentially only fromone or theother side of their victims. Thismakes themanideal model inwhich to investigatepotential laterality in neuroanatomyand transcription in the brain in relation to behavioral handedness. After determining behavioral handedness in P. microlepis (preferred attack side), we estimated the volume of the hemispheres of brainregions andcapturedtheir gene expressionprofiles. Our analyses revealedthat the degree of behavioralhandedness ismirrored at the level of neuroanatomical asymmetry, particularly in the tectumopticum. Transcriptome analyses showed that different brain regions (tectumopticum, telencephalon, hypothalamus, and cerebellum) display distinct expression patterns, potentially reflecting their developmental interrelationships. For numerous genes in each brain region, their extent of expression differences between hemispheres was found to be correlated with the degree of behavioral lateralization. Interestingly, the tectum opticum and telencephalon showed divergent biases on the direction of up- or down-regulation of the laterality candidate genes (e.g., grm2) in the hemispheres, highlighting the connection of handednesswith gene expression profiles and the different roles of these brain regions. Hence, handedness in predation behavior may be caused by asymmetric size of brain hemispheres and also by lateralized gene expressions in the brain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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