Phenols as Diamagnetic T2‐Exchange Magnetic Resonance Imaging Contrast Agents.

Autor:	Zhang, Jia, Li, Yuguo, Slania, Stephanie, Yadav, Nirbhay N., Liu, Jing, Wang, Rongfu, Zhang, Jianhua, Pomper, Martin G., Van zijl, Peter C., Yang, Xing, Liu, Guanshu
Předmět:	PHENOLS DIAMAGNETIC materials CONTRAST-enhanced magnetic resonance imaging METAL ions PROTONS THERAPEUTICS
Zdroj:	Chemistry - A European Journal; 1/26/2018, Vol. 24 Issue 6, p1259-1263, 5p
Abstrakt:	Abstract: Although T2‐exchange (T2ex) NMR phenomena have been known for decades, there has been a resurgence of interest to develop T2ex MRI contrast agents. One indispensable advantage of T2ex MR agents is the possibility of using non‐toxic and/or bio‐compatible diamagnetic compounds with intermediate exchangeable protons. Herein a library of phenol‐based compounds is screened and their T2ex contrast (exchange relaxivity, r2ex) at 9.4 T determined. The T2ex contrast of phenol protons allows direct detection by MRI at a millimolar concentration level. The effect of chemical modification of the phenol on the T2ex MRI contrast through modulation of exchange rate and chemical shift was also studied and provides a guideline for use of endogenous and exogenous phenols for T2ex MRI contrast. As a proof‐of‐principle application, phenol T2ex contrast can be used to detect enzyme activity in a tyrosinase‐catalyzed catechol oxidation reaction. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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