| Autor: |
da Silva, Mauro Roberto Biá, Brandão, Natália Alberto Alves, Colovati, Marco, de Sousa, Margella Marconcine Pinheiro, de Lima, Larissa Coelho, Dorta, Miriam Leandro, Ribeiro-Dias, Fátima, Costa, Dorcas Lamounier, Costa, Carlos Henrique Nery, de Oliveira, Milton Adriano Pelli |
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| Zdroj: |
Parasitology Research; Feb2018, Vol. 117 Issue 2, p419-427, 9p |
| Abstrakt: |
Because of visceral leishmaniasis (VL) urbanization and spreading of the human immunodeficiency virus (HIV) infection to rural areas, coinfection has become more common. Here, we compared the accuracy of Kalazar Detect® (KD), an rK39-based immunochromatographic (IC) test, and OrangeLife® (OL), an rK39 + rK28 IC test, for diagnosing VL in patients coinfected with HIV in an endemic area in Brazil. Seventy-six VL patients and 40 patients with other diseases, of which 31 and 21 patients, respectively, were infected with HIV, were examined. The sensitivity of OL and KD tests was 88.89 and 95.45%, respectively, in patients without HIV. The sensitivity dropped to 67.74 and 61.29%, respectively, in coinfected patients. The decrease in sensitivity was not related to a decrease in the production of Leishmania-specific IgG. Because of the low sensitivity of rk39 test in HIV-infected patients, we suggest that patients with negative rK39 results should undergo further investigation with additional serological tests that are not based only on the rK39 antigen and examination of bone marrow aspirates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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