Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers.

Autor:	Tew, Garry A., Gumber, Anil, McIntosh, Emma, Kesterton, Sue, King, Brenda, Michaels, Jonathan A., Klonizakis, Markos
Předmět:	MICROCIRCULATION disorders EXERCISE SODIUM nitroferricyanide COMPRESSION therapy DOPPLER effect LEG ulcers ULCER treatment BLOOD circulation BLOOD vessels COMPARATIVE studies EXERCISE therapy LEG RESEARCH methodology MEDICAL cooperation RESEARCH RESEARCH funding SKIN EVALUATION research RANDOMIZED controlled trials
Zdroj:	European Journal of Applied Physiology; Feb2018, Vol. 118 Issue 2, p321-329, 9p
Abstrakt:	Purpose: To investigate the effects of a 12-week supervised exercise programme on lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration.Methods: Thirty-eight adults with unilateral venous ulceration who were being treated with lower-limb compression therapy (58% male; mean age 65 years; median ulcer size 5 cm2) were randomly allocated to exercise or control groups. Exercise participants (n = 18) were invited to attend thrice weekly sessions of lower-limb aerobic and resistance exercise for 12 weeks. Cutaneous microvascular reactivity was assessed in the gaiter region of ulcerated and non-ulcerated legs at baseline and 3 months using laser Doppler fluxmetry coupled with iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP). Cutaneous vascular conductance (CVC) was calculated as laser Doppler flux (AU)/mean arterial pressure (mmHg).Results: Thirty-seven participants completed follow-up assessments. Median session attendance was 36 (range 2-36). Analyses of covariance revealed greater peak CVC responses to ACh in the exercise group at 3 months in both the ulcerated (adjusted difference = 0.944 AU/mmHg; 95% CI 0.504-1.384) and non-ulcerated (adjusted difference = 0.596 AU/mmHg; 95% CI 0.028-1.164) legs. Peak CVC responses to SNP were also greater in the exercise group at 3 months in the ulcerated leg (adjusted difference = 0.882 AU/mmHg; 95% CI 0.274-1.491), but not the non-ulcerated leg (adjusted difference = 0.392 AU/mmHg; 95% CI - 0.377 to 1.161).Conclusion: Supervised exercise training improves lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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