| Autor: |
Turner, Scott A., Deharvengt, Sophie J., Lyons, Kathleen Doyle, Espinal, Jorge Arturo Plata, LaRochelle, Ethan P.M., Bejarano, Suyapa, Kennedy, Linda, Tsongalis, Gregory J. |
| Předmět: |
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| Zdroj: |
Journal of Global Oncology; 2018, p1-8, 8p, 2 Diagrams, 2 Charts, 2 Graphs |
| Abstrakt: |
Purpose Cervical cancer is a leading cause of cancer-related mortality in low- and middle-income countries (LMICs) and screening in LMICs is extremely limited. We aimed to implement on-site highrisk human papillomavirus (hrHPV) DNA testing in cohorts of women from an urban factory and from a rural village. Methods A total of 802 women were recruited for this study in partnership with La Liga Contra el Cancer through the establishment of women’s health resource fairs at two locations in Honduras: a textile factory (n = 401) in the city of San Pedro Sula and the rural village of El Rosario (n = 401) in Yoro. Participants received a routine cervical examination during which three sterile cytobrushes were used to collect cervical samples for testing. hrHPV genotyping was performed using a hrHPV genotyping assay and a realtime polymerase chain reaction instrument. Results hrHPV status across all participants at both sites was 13%hrHPV positive and 67%hrHPV negative. When hrHPV status was compared across all three testing sites, hrHPV-positive rates were approximately equal among the factory (13%), village (12%), and confirmatory testing at Dartmouth-Hitchcock Medical Center (Lebanon, NH; 14%). hrHPV genotype was compared across sites, with HPV 16 showing the highest infection rate (15%), followed by HPV 59 (12%), and HPV 68 (11%). There was a low prevalence of HPV 18 observed in both populations compared with the hrHPV-positive population in the United States. Conclusion In collaboration with oncologists and pathologists from La Liga Contra el Cancer, we were able to provide a continuum of care once health-fair testing was performed. We established a method and implementation plan for hrHPV testing that is sustainable in LMICs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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