| Autor: |
Yool, D., Klugmann, M., Barrie, J. A., McCulloch, M. C., Nave, K.-A., Griffiths, I. R. |
| Předmět: |
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| Zdroj: |
Neuropathology & Applied Neurobiology; Feb2002, Vol. 28 Issue 1, p75-78, 4p |
| Abstrakt: |
Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a variety of defects at the intraperiod line (IPL) when prepared for conventional electron microscopy. The appearance of the PLP/DM20-deficient myelin prepared by freeze substitution showed a similar range of IPL defects to that prepared by conventional fixation and also included regions containing a normal IPL. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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