| Autor: |
Ajayi, Ayodeji Folorunsho, Akhigbe, Roland Eghoghosoa, Ajayi, Lydia Oluwatoyin |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); Oct-Dec2017, Vol. 8 Issue 4, p151-156, 6p, 6 Graphs |
| Abstrakt: |
Background: It is a known fact that altered thyroid state is associated with cardiometabolic disturbances. Raised TNF-α and lipid peroxidation have also been reported to be involved in the pathogenesis of cardiometabolic disorders. Aim: The present study evaluates the effect of dysthyroidism on cardiac TNF-α and lipid peroxidation, and whether the effect is estradiol-dependent. Methods: Male white New Zealand rabbits were randomized into three groups; control, carbimazole-induced hypothyroidism, and levothyroxine-induced hyperthyroidism. Results: Dysthyroidism led to altered glucose metabolism and dyslipidaemia with elevated LDL, TNF-α, and MDA. There was also decreased HDL, GSH, catalase, and 17β-estradiol. Serum electrolytes and hemorheological variables were not significantly affected. Conclusion: These findings demonstrate that dysthyroidism-induced cardiometabolic disturbance is associated with elevated cardiac TNF-α and oxidative stress via an estradiol-dependent mechanism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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