| Autor: |
Selinski, Silvia, Blaszkewicz, Meinolf, Ickstadt, Katja, Gerullis, Holger, Otto, Thomas, Roth, Emanuel, Volkert, Frank, Ovsiannikov, Daniel, Moormann, Oliver, Banfi, Gergely, Nyirady, Peter, Vermeulen, Sita H., Garcia-Closas, Montserrat, Figueroa, Jonine D., Johnson, Alison, Karagas, Margaret R., Kogevinas, Manolis, Malats, Nuria, Schwenn, Molly, Silverman, Debra T. |
| Předmět: |
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| Zdroj: |
Carcinogenesis; Dec2017, Vol. 38 Issue 12, p1167-1179, 13p |
| Abstrakt: |
Little is known whether genetic variants identified in genome-wide association studies interact to increase bladder cancer risk. Recently, we identified two-and three-variant combinations associated with a particular increase of bladder cancer risk in a urinary bladder cancer case-control series (Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), 1501 cases, 1565 controls). In an independent case-control series (Nijmegen Bladder Cancer Study, NBCS, 1468 cases, 1720 controls) we confirmed these two-and three-variant combinations. Pooled analysis of the two studies as discovery group (IfADo-NBCS) resulted in sufficient statistical power to test up to four-variant combinations by a logistic regression approach. The New England and Spanish Bladder Cancer Studies (2080 cases and 2167 controls) were used as a replication series. Twelve previously identified risk variants were considered. The strongest four-variant combination was obtained in never smokers. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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