| Autor: |
Shaban, Elkhabiry, Świtalska, Marta, Li Wang, Ning Wang, Fan Xiu, Ikuya Hayashi, Tran Anh Ngoc, Sachie Nagae, El-Ghlban, Samah, Shiho Shimoda, El Gokha, Ahmed Abdel Aleem, El Tantawy El Sayed, Ibrahim, Wietrzyk, Joanna, Tsutomu Inokuchi |
| Předmět: |
|
| Zdroj: |
Molecules; Nov2017, Vol. 22 Issue 11, p1954, 35p |
| Abstrakt: |
Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of topoisomerase II and shows antiproliferative activity. The present study describes the synthesis and antiproliferative evaluation of several neocryptolepine analogues carrying a branched, functionalized dibasic side chain at C11. These 2-substituted 5-methyl-indolo[2,3-b]quinoline derivatives were prepared by nucleophilic aromatic substitution (SNAr) of 11-chloroneocryptolepines with appropriate 1,2- and 1,3-diamines. Some of the 11-(ω-aminoalkylamino) derivatives were further transformed into 11-ureido and thioureido analogues. Many of the prepared neocryptolepine derivatives showed submicromolar antiproliferative activity against the human leukemia MV4-11 cell line. Among them, 11-(3-amino-2-hydroxy)propylamino derivatives 2h and 2k were the most cytotoxic with a mean IC50 value of 0.042 µM and 0.057 µM against the MV4-11 cell line, 0.197 µM and 0.1988 µM against the A549 cell line, and 0.138 µM and 0.117 µM against the BALB/3T3 cell line, respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
