| Autor: |
Coyne, J D, Banerjee, S S, Bromley, M, Mills, S, Diss, T C, Harris, M |
| Předmět: |
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| Zdroj: |
Histopathology; Apr2004, Vol. 44 Issue 4, p387-393, 7p |
| Abstrakt: |
Coyne J D, Banerjee S S, Bromley M, Mills S, Diss T C & Harris M (2004) Histopathology 44, 387–393 Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature To report the clinical, pathological and immunohistochemical features of three cases of post-transplant T-cell lymphoproliferative disorder (T-PTLD) T-cell lymphoma with primary cutaneous presentation. Three cases of primary cutaneous post-transplantation anaplastic large-cell lymphomas occurred in renal transplant recipients and were shown to display a T-cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein–Barr virus positive using in-situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T-cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. T-PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large-cell lymphoma but with a progressive clinical behaviour similar to previously reported T-PTLD and to systemic nodal ALK– anaplastic large-cell lymphoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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