An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water.

Autor: Liu, Xing, Liu, Min, Xu, Wan, Zeng, Meng-Tian, Zhu, Hui, Chang, Cai-Zhu, Dong, Zhi-Bing
Předmět:
Zdroj: Green Chemistry; 11/28/2017, Vol. 19 Issue 23, p5591-5598, 8p
Abstrakt: An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index