| Autor: |
Beus, Esther, Jager, Rosa L., Beeftink, Martine M., Sanders, Margreet F., Spiering, Wilko, Vonken, Evert ‐ Jan, Voskuil, Michiel, Bots, Michiel L., Blankestijn, Peter J., Elgersma, O, IJsselmuiden, AJJ, Valk, PHM, Smak Gregoor, P, Roodenburg, S, Meuwissen, M, Dewilde, W, Hunze, I, Hollander, J, Vincent, HH, Rensing, B |
| Zdroj: |
Journal of Clinical Hypertension; Nov2017, Vol. 19 Issue 11, p1125-1133, 9p |
| Abstrakt: |
The effect of lowering sympathetic nerve activity by renal denervation (RDN) is highly variable. With the exception of office systolic blood pressure (BP), predictors of the BP-lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24-hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension. Both 24-hour ambulatory and office BP measurements were end points. No relationship was found for baseline sodium excretion and change in BP 6 months after RDN in multivariable-adjusted regression analysis. Change in the salt intake-measured BP relationships at 6 months vs baseline was used as a measure for salt sensitivity. BP was 8 mm Hg lower with similar salt intake after RDN, suggesting a decrease in salt sensitivity. However, the change was similar in the control group, and thus not attributable to RDN. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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