| Abstrakt: |
An approach using method validation (MV) parameters, otherwise known as analytical figures of merit was combined with electrospray ionization high performance ion mobility spectrometry (ESI-HPIMS) to describe an approach for evaluating drugs and explosives analysis in the field. MV parameters such as reduced mobility ( K ), conditional reduced mobility ( K ), resolving power ( R ), theoretical plates ( N), linearity, accuracy, precision, limit of detection (LOD), limit of quantitation (LOQ), repeatability, range, and reporting limit were investigated and developed for eleven drugs and six explosives. Our investigation estimated resolving power at 66 ± 0.64 for the ESI-HPIMS used. The LOD's calculated ranged from 0.45-2.97 ng of material electrosprayed into the ESI-HPIMS. The LOQ's calculated falls in the range 4.11-8.63 ng of material electrosprayed into the ESI-HPIMS. The key findings from this investigation were the following: K proves to be a measure of the identity of an explosive or drug ion; a parameter that may be applied to help aid IMS devices when detecting drugs and explosives. MV parameters, especially, K , introduced in this study is an effective parameter for establishing a unique identity of a drug or explosive. A control chart is an effective way to monitor the performance of an instrument and may be a useful tool for establishing reliability of confirmatory data in forensic investigations. MV parameters may be a reliable, accurate and unique identification marker for target drugs and explosives capable of differentiating these substances from false positive responses. [ABSTRACT FROM AUTHOR] |
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