Successful treatment of refractory peripheral T-cell lymphoma with a combination of fludarabine and cyclophosphamide.

Autor: Yamaguchi, Masaki, Kotani, Takeharu, Nakamura, Yoshihisa, Ueda, Mikio
Zdroj: International Journal of Hematology; Jun2006, Vol. 83 Issue 5, p450-453, 4p
Abstrakt: We report a case of refractory peripheral T-cell lymphoma (PTCL) successfully treated with a combination of fludarabine and cyclophosphamide (FLU/CY). A 68-year-old man with concurrent PTCL and diffuse large B-cell lymphoma was treated effectively with 3-course CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy, but PTCL relapse occurred and was resistant to ESHAP (etoposide, methylprednisolone, cytarabine, and cisplatin) therapy. FLU/CY therapy led to complete remission, which was maintained for almost 14 months after a single course. We concluded that a FLU/CY regimen may be useful for attaining long-term remission in patients with refractory relapsed PTCL and should therefore be considered a valuable treatment choice. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index