| Autor: |
Ota, Shuichi, Tanaka, Junji, Kahata, Kaoru, Toubai, Tomomi, Kondo, Keiichi, Mori, Akio, Toyoshima, Nobuyasu, Musashi, Manabu, Asaka, Masahiro, Imamura, Masahiro |
| Předmět: |
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| Zdroj: |
International Journal of Hematology; May2004, Vol. 79 Issue 4, p390-393, 4p |
| Abstrakt: |
We treated a 52-year-old woman with acute lymphoblastic leukemia (ALL) who developed invasive pulmonary aspergillosis (IPA) as a result of neutropenia following remission-induction chemotherapy. Although serological test results, such as those for platelia and pastrex, were all negative and the serum level of beta-D-glucan was low, Aspergillus DNA was detected in blood by the polymerase chain reaction method. A clinically documented diagnosis of IPA was made on the basis of chest x-rays, computed tomography scan findings, and the detection of Aspergillus DNA. Micafungin (FK463), a candin class antifungal agent, was administered at a dose of 75 to 150 mg/day, because other antifungal agents were not effective. The increase in serum concentration of micafungin was dose-dependent and was accompanied by improvement of symptoms and objective findings. Micafungin was effective for the treatment of IPA in this patient with ALL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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