Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients.
| Autor: | Dupont, Laust, Anders Eide, Ivar, Hartmann, Anders, Hagstrup Christensen, Jeppe, Åsberg, Anders, Jenssen, Trond, Krarup, Henrik, Svensson, My |
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| Předmět: |
CARDIOVASCULAR disease related mortality
CARDIOVASCULAR diseases risk factors CHI-squared test CONFIDENCE intervals GENES GRAFT versus host reaction IMMUNOSUPPRESSION KIDNEY transplantation LONGITUDINAL method T-test (Statistics) TRANSPLANTATION of organs tissues etc. MATHEMATICAL variables WHITE people PROPORTIONAL hazards models RETROSPECTIVE studies MANN Whitney U Test GENOTYPES |
| Zdroj: | Progress in Transplantation; Dec2017, Vol. 27 Issue 4, p386-391, 6p |
| Abstrakt: | Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied.~Background~Background~In this single-center retrospective cohort study of 1975 adult Norwegian transplant recipients, who underwent transplantation between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death-censored graft loss for patients with haptoglobin genotype 2-2 compared to genotype 2-1 or 1-1, after adjustment for confounders and competing risks.~Methods~Methods~We found no associations between haptoglobin genotype 2-2 and cardiovascular mortality (subdistributional hazard ratio 1.08, 95% confidence interval 0.78-1.49; P = .63). We also failed to detect any association between haptoglobin 2-2 genotype and all-cause mortality, overall graft loss, and death-censored graft loss. Similar results were found in the subpopulation of transplant recipients with diabetes.~Results~Results~In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2-2 genotype and patient or graft survival after renal transplantation.~Conclusion~Conclusions [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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