Atypical Clinical Presentations of Acute Phase Chikungunya Virus Infection in Older Adults.
Autor: | Godaert, Lidvine, Najioullah, Fatiha, Bartholet, Seendy, Colas, Sébastien, Yactayo, Sergio, Cabié, André, Fanon, Jean‐Luc, Césaire, Raymond, Dramé, Moustapha |
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Předmět: |
CHIKUNGUNYA virus
DISEASES in older people CLINICAL medicine INFECTION CHIKUNGUNYA UTILIZATION of hospital emergency service REVERSE transcriptase polymerase chain reaction DIAGNOSIS PATIENTS CROSS-sectional method ACADEMIC medical centers AGE distribution PROBABILITY theory STATISTICAL sampling DESCRIPTIVE statistics SYMPTOMS OLD age |
Zdroj: | Journal of the American Geriatrics Society; Nov2017, Vol. 65 Issue 11, p2510-2515, 6p, 3 Charts |
Abstrakt: | Objectives We aimed to determine whether the presentation of Chikungunya virus ( CHIKV) infection differs between older and younger adults with regard to clinical form during the acute phase defined by the World Health Organization: acute clinical, atypical, and severe acute. Design Cross-sectional, retrospective. Setting University Hospital of Martinique. Participants Individuals aged 65 and older (n = 267, mean age 80.4 ± 87.9) who attended the emergency department with a positive biological diagnosis of CHIKV (reverse transcriptase polymerase chain reaction) between January and December 2014 and a randomly selected sample of individuals younger than 65 (n = 109, mean age 46.2 ± 12.7). Results Typical presentation was present in 8.2% of older adults and 59.6% of younger individuals ( P < .001), atypical presentation in 29.6% of older adults and 5.6% of younger individuals ( P < .001), and severe presentation in 19.5% of older adults and 17.4% of younger individuals ( P = .65). One hundred fourteen (42.7%) of the older group and 19 (17.4%) of the younger group could not be classified in any category (absence of fever, absence of joint pain, or both) ( P < .001). Conclusion Only 8.2% of the older adults presenting in the acute phase of CHIKV have typical forms, suggesting that the most-frequent clinical presentation of CHIKV in older adults differs from that in younger individuals. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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