| Autor: |
Silva Vasconcelos, Wellyton, da Silva, Gilvaldo Gentil, Alves Junior, Severino, dos Anjos, Janaína Versiani, da Cunha Areias, Madalena Carneiro |
| Předmět: |
|
| Zdroj: |
Electroanalysis; Nov2017, Vol. 29 Issue 11, p2572-2578, 7p |
| Abstrakt: |
We report in this work, a new method for the determination of captopril by differential pulse voltammetry using a glassy carbon electrode modified with a copper metal-organic framework (H-Kust-1 or Cu3(BTC)2 or Cu-BTC), immobilized on the surface by a copolymer of acrylamide and sodium acrylate. This compound is detected by the formation of a copper(II)-captopril complex that is observed in an oxidation potential at ca. +0.28 V vs. Ag/AgCl. A linear dynamic range is obtained for a captopril concentration of 0.5 μM to 7.0 μM and the voltammetric response is highly reproducible within 3.52 % error. The sensitivity of 9.71±0.37 nA μM−1 and the limit of detection of 0.20±0.01 μM make this methodology highly applicable for practical applications. The determination of captopril in a commercial pharmaceutical sample showed a recovery of 93.3 %. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
