Selective Carboxylate Directed ortho Functionalization in Copper Catalyzed Reactions of Polyiodo Aromatics: A Straightforward Preparation of 5,7-Diiodo-1H-isochromen-1-ones.

Autor:	Anselmi, Elsa, Bahlaouan, Zineb, Inack Ngi, Samuel, Parrain, Jean Luc, Magnier, Emmanuel, Abarbri, Mohamed
Předmět:	COPPER catalysts CARBOXYLATES REGIOSELECTIVITY (Chemistry) CUPROUS iodide ISOCOUMARINS
Zdroj:	European Journal of Organic Chemistry; 11/9/2017, Vol. 2017 Issue 41, p6131-6136, 6p
Abstrakt:	A facile, and totally regioselective one-pot approach to synthesize 5,7-diiodo-3-substituted-isocoumarins is described. This reaction was realized by using copper iodide as the catalyst under mild reaction conditions. The methodology was used to design a wide variety of compounds and was tolerant to a large number of functional groups. Interestingly, among the three possible carbon-iodine bonds, only one was reactive, which left the two others intact for further functionalization. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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