| Autor: |
Rawat, Jagveer, Dixon, John B., MacIntyre, Andrew R., McGarry, Helen F., Taylor, Mark J. |
| Předmět: |
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| Zdroj: |
Parasite Immunology; Nov2003, Vol. 25 Issue 11/12, p553-557, 5p |
| Abstrakt: |
Three-week Mesocestoides corti infections of C57BL/6 mice showed significantly raised parasite counts in animals with a targeted knockout of the IL-4 gene. By contrast, antibody neutralization of IL-5 and inhibition of eosinophilia had no effect on parasite numbers. In SV/129 mice, knockout of the interferon γ receptor and inducible nitric oxide synthase genes had no significant effect on parasite counts. In IL-4 –/– mice the dominant IgG1 antibody response was dramatically reduced, with a concomitant increase in IgG2a/b responses and a partial twofold reduction in IgM and IgE responses. We conclude that murine resistance to M. corti is dependent on IL-4, but occurs independently of IL-5 and eosinophils. This provides the first direct evidence for IL-4 mediated immunity of mice to infection with a tissue-dwelling platyhelminth. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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