New reagent for the introduction of Boc protecting group to amines: Boc-OASUD.

Autor:	Maheswara Rao, B. Leela, Nowshuddin, Shaik, Jha, Anjali, Divi, Murali K., Rao, M. N. A.
Předmět:	CHEMICAL reagents CARBONATES AMINO acids ESTERS RACEMIZATION
Zdroj:	Synthetic Communications; 2017, Vol. 47 Issue 22, p2127-2132, 6p, 4 Diagrams, 1 Chart
Abstrakt:	A new reagent, tert-butyl (2,4-dioxo-3-azaspiro [5,5] undecan-3-yl) carbonate (Boc-OASUD) for the preparation of N-Boc-amino acids is described. The Boc-OASUD reacts with amino acids and their esters at room temperature in the presence of a base and gives N-Boc-amino acids and their esters in good yields and purity. Introduction of the Boc group takes place without racemization. The Boc-OASUD, being a solid and more stable, is a better alternative to di-tert-butyl dicarbonate which is low melting and has to be dispensed in plastic containers than glass because of its poor stability. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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