| Autor: |
de J. Parra, Yonathan, Ferrer M., Rosa E., Bruno-Colmenarez, Julia, Charris, Jaime, Lobo, Gricela, de Domínguez, Neira Gamboa, Rosenthal, Philip J., Gut, Jiri |
| Předmět: |
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| Zdroj: |
Orbital: The Electronic Journal of Chemistry; Jul-Sep2017, Vol. 9 Issue 4, p308-314, 7p |
| Abstrakt: |
A simple synthesis and study by UV-vis, IR, NMR, ESI-CID-MS² and X-ray diffraction of ((2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarbothioamide is reported. It was tested in vitro against chloroquine-resistant strain (W2) of Plasmodium falciparum, hemozoin (β-hematin) formation and cysteine protease falcipain-2. In general, it was found to possess a proved activity in its inhibitory power on the parasite but less active on the formation of hemozoin (β-hematin) and falcipain-2. Also, the X-ray analysis presented an unexpected electronic density that can be assigned like S(2). This electronic density can be attributed to autocondensation of thiosemicarbazide, generating H2S as a subproduct. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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