Nitric oxide-c GMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts.

Autor: Tatsumi, Tetsuya, Keira, Natsuya, Akashi, Kazuko, Kobara, Miyuki, Matoba, Sataoaki, Shiraishi, Jun, Yamanaka, Satoshi, Mano, Akiko, Takeda, Mitsuo, Nishikawa, Susumu, Asayama, Jun, Fliss, Henry, Nakagawa, Masao
Předmět:
Zdroj: Journal of Applied Physiology; Mar2004, Vol. 96 Issue 3, p853-860, 8p, 3 Charts, 11 Graphs
Abstrakt: Examines the involvement of nitric oxide (NO) in the mechanisms by which endotoxemia causes cardiac depression. Infusion of rats with lipopolysaccharide (LPS) or saline; Isolation of hearts and mounting in a Langendorff apparatus; Determination of the left ventricular developed pressure before biochemical analysis of the myocardium; Finding that the myocardial adenosine triphosphate levels were not significantly altered after LPS injection.
Databáze: Complementary Index