| Autor: |
Botasheva, Tatiana, Pelipenko, I. G., Lebedenko, E. Y., Zavodnov, O. P., Shubitidze, M. G. |
| Předmět: |
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| Zdroj: |
Journal of Perinatal Medicine; 2017 Supplement, Vol. 45, p299-299, 1p |
| Abstrakt: |
The aim of the study is development of method for the prevention of threatening preterm labor and abortion with the use of partial light deprivation with polycarbonate lenses. 184 nulliparous women with the threat of pregnancy loss aged 18-27 years were examined at the gestational age of 15-22 weeks: 56 women, who had partial light deprivation and standard therapy (group I); 58 women received only standard therapy (group II). In women of the I clinical group, partial light deprivation in a natural light with optical lenses with a photochromic coating was performed with standard therapy (vaginal micronized progesterone 400 mg/day, folic acid 400 mg/day). The use of glasses with light-protective lenses was carried out daily in conditions of staying in the open sun for at least 30 days from May to October in women of 15-22 weeks of pregnancy. Women of the II clinical group received only standard therapy. The study of hormonal status (the level of progesterone, luteinizing and follicle-stimulating hormones) was performed. To assess the secretion of melatonin, urine of pregnant women was collected twice (at 8 am and 8 pm) and analyzed by ELISA BUHLMANN, Germany, the level of its main metabolite of 6-sulfatoxymeelatonin was determined by the method of enzyme immunoassay. The modulating effect of light deprivation on melatonin metabolism was revealed when using polycarbonate lenses, which was expressed by a statistically significant increase by 2.5 times in the level of 6-sulphatoxymelatonin in women's morning urine, and an increase in the level of progesterone by 40.21% and decrease in the level of gonadotropic hormones (luteinizing hormone - by 39.26% and follicle-stimulating hormone - by 36.75%). Frequency of threatening pregnancy loss in I clinical group was 1.9 times lower compared to group II. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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