| Autor: |
Sachie Suga, Ichiro Yasuhi, Makoto Nomiyama, Tomoya MIzunoe, Naofumi Okura, Kosuke Kawakami, Masanobu Ogawa, Takashi Kodama, Katsuhiko Tada, Moe Yorozu, Yuka Maekawa, Masahiro Sumitomo, Kazuhisa Maeda, Kimikazu Hayashi |
| Předmět: |
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| Zdroj: |
Journal of Perinatal Medicine; 2017 Supplement, Vol. 45, p208-208, 1p |
| Abstrakt: |
Objective: In some cases with light-for-date (LFD) infants born at late preterm and term, we cannot find any causes associated with fetal growth restriction (FGR). The management protocol is still unclear in such idiopathic FGR cases. We aimed to demonstrate risk factors associated with adverse neonatal outcomes in cases with idiopathic LFD infants born at late preterm and term. Methods: This is a retrospective multicenter study in Japan, we included cases with a LFD infant born at 34 weeks' gestation or later whose cause of growth restriction was not clinically identified in either maternal, fetal, or placental conditions in singleton pregnancies. We defined combined neonatal complications including respiratory disorders, clinical hypoglycemia, and hyperbilirubinemia as adverse neonatal outcomes. We investigated maternal and perinatal factors associated with adverse neonatal outcomes. Results: We included 686 singleton pregnancy cases of a LFD infant born at late preterm and term in 2011-2013. Among them, we identified 404 (59%) cases of idiopathic FGR. The diagnosis of FGR during pregnancy was made in 67% of the cases. In multivariate analysis, GA at delivery (adjusted- OR 0.64 [95%CI 0.54-0.76]) and BW z-score (a-OR 0.40 [95%CI 0.22-0.71]) were independently associated with the adverse neonatal outcomes. Regarding cases with a late preterm LFD infant, only the diagnosis of FGR during pregnancy was a significant predictor of the adverse neonatal outcomes (a-OR 7.56 [95%CI 1.84-33.5]). Conclusions: In singleton idiopathic LFD infants born at late preterm and term, GA at delivery and severity of growth restriction were associated with the adverse neonatal outcomes. In terms of late preterm LFD infants, the diagnosis of FGR during pregnancy was an only predictor of adverse neonatal outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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