| Abstrakt: |
Objective. To evaluate changes in "Growth Hormone (Gh) - Insulin-Like Growth Factor (Igf-1)" axis and insulin sensitivity in infants with asymmetrical and symmetrical intrauterine growth retardation (IUGR) in association with postnatal growth. Methods. Forty infants with IUGR (24 with asymmetrical and 16 with symmetrical type and 17 appropriate for gestational age (AGA)) were followed for 6 months after birth. The fasting GH, IGF-1, insulin and glucose serum levels were measured at 3 and 6 months of age. Insulin sensitivity was evaluated by HOMA-IR. Body weight and length were measured at birth, at 3 and 6 months of age. "Catch-up" growth was determined as a weight and/or length gain from less than 10th percentile to 50th percentile during months 0 to 3 or months 3 to 6. Results are shown as ME (25-75%). Results. "Catch - up" growth was observed in infants with asymmetrical (72.8%) and symmetrical (62.5%) IUGR during first three months. at 3 months of age, symmetrical IUGR infants with "catch - up" growth had higher IGF-1 (128.0(102.5-131.5) NG/ML), and GH (9.0(4.76-11.5) NG/ML) levels compared to asymmetrical IUGR infants with "catch - up" growth (64.0(51.5-110.0) NG/ML, 1.97(1.3-4.2) NG/ML, P<0.05, RESP.) and controls (75,0(52.0-101.0) NG/ML, 3.15(1.9-4.3) NG/ML, P<0.05, RESP.). HOMA-IR was higher in symmetrical IUGR infants compared to controls (1.09(0.9- 1.6) VS 0.8(0.4-0.9), P<0.05). At 6 months of age, the IGF-1, GH levels and HOMA-IR in symmetrical IUGR infants (60.7(41.4-126.2) NG/ML, 3.0(2.5-4.2) NG/ML, 0.57(0.3-0.7), P<0.05, RESP.) decreased compared to those obtained at 3 months. Asymmetrical IUGR infants with "catch - up" growth were similar in IGF-1, GH levels and HOMA-IR at 3 and 6 months of age. Conclusions. higher GH, IGF-1 levels and HOMA-IR at 3 months of age in symmetrical IUGR infants with "catch - up" growth are associated with more intensive growth velocity (weight and length gain). [ABSTRACT FROM AUTHOR] |
