Co-existence of Diffuse Serous Cystadenoma and Pancreatic Neuroendocrine Tumor.

Autor: Tewari, Mallika, Patne, Shashikant, Katiyar, Richa, Biswas, Dipanjan, Shukla, HS
Předmět:
Zdroj: Indian Journal of Surgery; Oct2017, Vol. 79 Issue 5, p455-457, 3p
Abstrakt: Diffuse serous cystic neoplasm (SCN) associated with pancreatic neuroendocrine tumor (PNET) is a rare finding reported previously in only three patients to the best of our knowledge. We herein present one such interesting report of a diffuse serous cystic adenoma (SCA) and co-existent PNET in a 25-year old lady who presented with abdominal pain for past 6 months. A triple-phase pancreatic protocol computed tomography (CT) scan revealed multiple cysts involving the entire pancreas. The cysts were thin walled, ranging from 2 to 8 cm in width, with no calcification or central scar that was confirmed at laparotomy. A frozen section revealed a neuroendocrine tumor and she underwent total pancreatectomy. Diffuse SCA with co-existent PNET infiltrating nerve bundles of the pancreatic parenchyma was made upon histopathology further verified by chromogranin-A immunostaining. The patient is insulin dependent and doing well at 2 years of follow-up. The origin of endocrine tumors from multipotent ductular stem cells has been suggested. [ABSTRACT FROM AUTHOR]
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