| Autor: |
Faleiro, Inês, Apolónio, Joana Dias, Price, Aryeh J, De Mello, Ramon Andrade, Roberto, Vânia Palma, Tabori, Uri, Castelo-Branco, Pedro, Faleiro, Inês, Apolónio, Joana Dias, Roberto, Vânia Palma |
| Zdroj: |
Future Oncology; Oct2017, Vol. 13 Issue 23, p2045-2051, 7p |
| Abstrakt: |
Aim: We explore the biomarker potential of the TERT hypermethylated oncologic region (THOR) in pancreatic cancer.Materials& Methods: We assessed the methylation status of THOR using the cancer genome atlas data on the cohort of pancreatic cancer (n = 193 patients).Results: THOR was significantly hypermethylated in pancreatic tumor tissue when compared with the normal tissue used as control (p < 0.0001). Also, THOR hypermethylation could distinguish early stage I disease from normal tissue and was associated with worse prognosis.Discussion: We found that THOR is hypermethylated in pancreatic tumor tissue when compared with normal tissue and that THOR methylation correlates with TERT expression in tumor samples.Conclusion: Our preliminary findings support the diagnostic and prognostic values of THOR in pancreatic cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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