| Autor: |
Lisboa Neto, Gaspar, Malta, Fernanda M., Gomes-Gouvêa, Michele S., Noble, Caroline F., Romano, Camila M., Rebello Pinho, João R., Silva, Mariliza H., Leite, Andrea G.B., Piccoli, Leonora Z., Carrilho, Flair J., Mendes-Correa, Maria C. |
| Zdroj: |
Journal of Medical Virology; Dec2017, Vol. 89 Issue 12, p2249-2254, 6p |
| Abstrakt: |
Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6-2.4%), V55A (7-2.8%), and Q80R (2-0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs. Advanced liver fibrosis and HIV co-infection were not related to NS3/NS4A amino acid substitutions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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