| Autor: |
Pereira‐Fonseca, D. C. M., Oliveira‐Rovai, F. M., Rodas, L. A. C., Beloti, C. A. C., Torrecilha, R. B. P., Ito, P. K. R. K., Avanço, S. V., Cipriano, R. S., Utsunomiya, Y. T., Hiramoto, R. M., Calvo‐Bado, L., Courtenay, O., Machado, G. F., Lima, V. M. F., Nunes, C. M. |
| Předmět: |
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| Zdroj: |
Parasite Immunology; Nov2017, Vol. 39 Issue 11, pn/a-N.PAG, 7p |
| Abstrakt: |
Visceral leishmaniosis is a zoonotic disease that is transmitted by Lutzomyia longipalpis sandflies. Dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. Type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumour necrosis factor alpha ( TNF-α). In contrast, Type 2 immunity is predominantly humoral, associated with progression of the disease and mediated by anti-inflammatory cytokines such as interleukin 10 ( IL-10). Although seemly important in the dynamics of leishmaniosis, other gene products such as toll-like receptor 2 ( TRL-2) and inducible nitric oxide synthase ( iNOS) exert unclear roles in the determination of the type of immune response. Given that the dog skin serves as a micro-environment for the multiplication of Leishmania spp., we investigated the parasite load and the expression of TLR-2, iNOS, IL-10 and TNF-α in the skin of 29 infected and 8 control dogs. We found that increased parasite load leads to upregulation of TLR-2, IL-10 and TNF-α, indicating that abundance of these transcripts is associated with infection. We also performed a xenodiagnosis to demonstrate that increased parasitism is a risk factor for infectiousness to sandflies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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