Association between disease activity and quality of life in ulcerative colitis: Results from the CRONICA-UC study.

Autor: Panés, Julián, Domènech, Eugeni, Aguas Peris, Marian, Nos, Pilar, Riestra, Sabino, Juliá de Páramo, Berta, Cea‐Calvo, Luis, Romero, Cristina, Marín‐Jiménez, Ignacio
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Zdroj: Journal of Gastroenterology & Hepatology; Nov2017, Vol. 32 Issue 11, p1818-1824, 7p, 3 Charts, 1 Graph
Abstrakt: Background and Aim In ulcerative colitis (UC), the main goals of treatment are to control disease activity and normalize health-related quality of life (HRQoL). In this study, we explored the relationship between disease activity (measured using the Simple Clinical Colitis Activity Index [SCCAI]) and patient HRQoL (measured using the EuroQoL [EQ]-5D-5L). Methods A total of 199 patients with UC were followed for 6 months. At months 3 and 6, patients completed an online SCCAI. Within 2 days of completing the SCCAI, patients completed an at-clinic EQ-5D-5L questionnaire and the treating gastroenterologist completed the SCCAI. Results A consistent and approximately linear relationship was identified between patient HRQoL and patient-completed and physician-completed SCCAIs. A lower SCCAI score corresponded to a higher EQ-5D-5L index value. Correlation between EQ-5D-5L index values and patient-completed online SCCAIs was moderate (ρ −0.49; P < 0.001) and similar to that between EQ-5D-5L index values and physician-completed SCCAIs (ρ −0.53; P < 0.001). A decrease in the EQ-5D-5L index was already observed at an SCCAI score of 2, commonly regarded as remission. A 1-point increase in the patient SCCAI corresponded to an average change of −0.027 (standard deviation, −0.032 to −0.022) in the EQ-5D-5L index, whereas a 1-point increase in the physician SCCAI corresponded to an average change of −0.030 (standard deviation, −0.036 to −0.025). Conclusions Health-related quality of life measured using the EQ-5D-5L questionnaire is proportionally related to disease activity in patients with UC. In line with the treat-to-target objective in UC, complete control of all symptoms is required to achieve optimal improvement in patient HRQoL. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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