Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalis.

Autor:	Chu, Pao-Hsien, Yeh, Hung-I, Jung, Shih-Ming, Chien, Li-Ying, Cheng, Nai-Feng, Wu, Hsueh-Hua, Chu, Jaw-Ji, Hsueh, Chuen, Lee, Ying-Shiung
Předmět:	ADIPOSE tissues COMPARATIVE studies ECHOCARDIOGRAPHY ELECTROCARDIOGRAPHY HEART diseases IMMUNOHISTOCHEMISTRY RESEARCH methodology MEDICAL cooperation MEMBRANE proteins MICROSCOPY RESEARCH EVALUATION research HAMARTOMA
Zdroj:	Virchows Archiv: European Journal of Pathology; Apr2004, Vol. 444 Issue 4, p383-386, 4p
Abstrakt:	Cardiac hamartomas are very rare and are demarcated masses of enlarged, hypertrophied, mature myocytes and collagen tissue. Cardiac hamartomas are generally circumscribed in the right ventricle or atrium, but not reported in the crista terminalis (CRT). The CRT is crucial in electrophysiology, is related to arrhythmogenesis, and is targeted by radiofrequency catheter procedures. Previous works only described the benign natures of prominent CRT using non-invasive methods. This study describes an unusual cardiac hamartoma originating from the CRT and extending toward the tricuspid valve. Microscopically, this hamartoma comprised dense collagen and adipose tissue, mixed with hypertrophy, but with disarrayed cardiomyocytes. An irregular gap junction, connexin43, was demonstrated in this cardiac hamartoma. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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