Studies on the virulence properties and metabolism of pleiotropic mutants of Porphyromonas gingivalis (Bacteroides gingivalis) W50.

Autor: Shah, H. N., Seddon, S. V., Gharbia, S. E.
Předmět:
Zdroj: Oral Microbiology & Immunology; Mar1989, Vol. 4 Issue 1, p19-23, 5p
Abstrakt: Porphyromonas gingivalis (Bacteorides gingivalis) strain W50 and variants isolated from continuous culture designated W50/BPI (black pigmented), W50/BR1 (brown pigmented) and W50/BE 1 (beige or non-pigmented) were previously shown to lose virulence with the loss of pigmentation (8). Major properties which may affect the virulence and metabolism of P. gingivalis were compared amongst the 4 strains. The non-pigmented strain lost the ability to hemagglutinate sheep erythrocyte, had a reduced hydrophobicity and possessed lower levels of proteolytic activity. Defects in the electron transport system occurred at the level of cytochrome b but not menaquinone synthesis and resulted in an altered metabolic end product profile of the non-pigmented strain. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index