Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly ( d , l -lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis.

Autor:	Yang, Haibo, Hao, Yujie, Liu, Qiming, Mi, Zhanhu, Wang, Zhibin, Zhu, Lei, Feng, Qingling, Hu, Ningmin
Předmět:	EMULSIONS MICROSPHERES ANTIBACTERIAL agents MICROENCAPSULATION LACTIDES OSTEOMYELITIS treatment
Zdroj:	Artificial Cells, Nanomedicine & Biotechnology; Nov2017, Vol. 45 Issue 7, p1326-1330, 5p
Abstrakt:	HNV-loaded PLGA microspheres (HNV-PLGA MSs) were prepared by water-in-oil-in-water (w/o/w) double emulsion solvent evaporation technique. The surface of prepared HNV-PLGA MSs is smooth and nonporous with an average diameter of 69.9 μm. The drug-loading rate and encapsulation rate of HNV-PLGA MSs are 4.40 ± 0.26% and 48.51 ± 14.83%, respectively. Additionally, 43.36% of HNV was released from PLGA MSs after seven days of incubation. The antibacterial effects of HNV released from PLGA were as good as the pure HNV. HNV-loaded PLGA microspheres were successfully prepared using double emulsion solvent evaporation technique and their properties met the requirements for local anti-infection. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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