| Autor: |
Xu, Cheng, Messina, Andrea, Somm, Emmanuel, Miraoui, Hichem, Kinnunen, Tarja, Acierno, James, Niederländer, Nicolas J, Bouilly, Justine, Dwyer, Andrew A, Sidis, Yisrael, Cassatella, Daniele, Sykiotis, Gerasimos P, Quinton, Richard, De Geyter, Christian, Dirlewanger, Mirjam, Schwitzgebel, Valérie, Cole, Trevor R, Toogood, Andrew A, Kirk, Jeremy MW, Plummer, Lacey |
| Zdroj: |
EMBO Molecular Medicine; Oct2017, Vol. 9 Issue 10, p1379-1397, 19p |
| Abstrakt: |
Congenital hypogonadotropic hypogonadism ( CHH) is a rare genetic form of isolated gonadotropin-releasing hormone (Gn RH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 ( FGFR1) is the most frequently mutated gene in CHH and is implicated in Gn RH neuron development and maintenance. We note that a CHH FGFR1 mutation (p.L342S) decreases signaling of the metabolic regulator FGF21 by impairing the association of FGFR1 with β-Klotho ( KLB), the obligate co-receptor for FGF21. We thus hypothesized that the metabolic FGF21/ KLB/ FGFR1 pathway is involved in CHH. Genetic screening of 334 CHH patients identified seven heterozygous loss-of-function KLB mutations in 13 patients (4%). Most patients with KLB mutations (9/13) exhibited metabolic defects. In mice, lack of Klb led to delayed puberty, altered estrous cyclicity, and subfertility due to a hypothalamic defect associated with inability of Gn RH neurons to release Gn RH in response to FGF21. Peripheral FGF21 administration could indeed reach Gn RH neurons through circumventricular organs in the hypothalamus. We conclude that FGF21/ KLB/ FGFR1 signaling plays an essential role in Gn RH biology, potentially linking metabolism with reproduction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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