| Autor: |
Ronchetti, Domenica, Neglia, Cesare B., Cesana, Bruno M., Carboni, Nadia, Neri, Antonio, Pruneri, Giancardo, Pignataro, Lorenzo |
| Předmět: |
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| Zdroj: |
Archives of Otolaryngology - Head & Neck Surgery; Mar2004, Vol. 130 Issue 3, p303-306, 4p |
| Abstrakt: |
Objectives: To analyze the relationship between p53 gene mutations, tobacco smoke, and alcohol consumption in patients with laryngeal squamous cell carcinoma. Design: We analyzed p53 gene mutations in exons 5 through 8 by polymerase chain reaction–single-strand conformation polymorphism analysis in a cohort of 84 patients with laryngeal squamous cell carcinoma. Setting: University hospital. Results: p53 gene mutations were detected in 24 (28.6%) cases (95% confidence interval, 19.3%-39.5%), and the GC to TA transversion (33%) was the most common type of mutation (95% confidence interval, 15.6%-55.3%). Most mutations mapped to the p53 DNA-binding domain, which is necessary for the physiological activity of p53 as a tumor suppressor. A statistically significant association was found between p53 mutations and exposure to tobacco smoke (P = .001), which was the only variable significantly associated with p53 mutations in a multivariate model. The association with alcohol consumption was only at a borderline level of significance (P = .065). Conclusion: Our data document that a smoking habit is the only independent variable associated with an increased risk of p53 mutations in the laryngeal mucosa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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