Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification.

Autor: Yang, Xianbin, Dinuka Abeydeera, N., Liu, Feng-Wu, Egli, Martin
Předmět:
Zdroj: Chemical Communications; 9/28/2017, Vol. 53 Issue 76, p10508-10511, 4p
Abstrakt: The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA–protein interactions triggered by the PS2 moiety. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index