A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[ b,f]1,8-naphthyridine Derivatives.

Autor:	Villuri, Bharath Kumar, Konala, Ashok, Kavala, Veerababurao, Kotipalli, Trimurtulu, Kuo, Chun ‐ Wei, Yao, Ching ‐ Fa
Předmět:	NAPHTHYRIDINES COPPER catalysts NUCLEOPHILIC addition (Chemistry) kinetics ALKYNE synthesis NITRILE synthesis
Zdroj:	Advanced Synthesis & Catalysis; Sep2017, Vol. 359 Issue 18, p3142-3153, 12p
Abstrakt:	The synthesis of some dibenzo[ b,f]-[1,8]naphthyridine derivatives in a cascade manner is reported. The reaction includes a Knovenagel condensation, the insertion of a nitrile and an alkyne into an N-H bond and an oxidation/oxidative C-C bond cleavage sequence in the presence of copper iodide. The key 1,8-naphthyridine core was constructed in a cascade manner during the course of the reaction itself which allows diverse dibenzo[ b,f]-[1,8]naphthyridine derivatives to be readily prepared. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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