| Autor: |
Jenner, Raimundo, Fatureto ‐ Borges, Fernanda, Costa ‐ Hong, Valéria, Lopes, Heno F., Teixeira, Sandra H., Marum, Elias, Giorgi, Dante A. M., Consolim ‐ Colombo, Fernanda M., Bortolotto, Luiz A., Lorenzi ‐ Filho, Geraldo, Krieger, Eduardo M., Drager, Luciano F., Fatureto-Borges, Fernanda, Costa-Hong, Valéria, Consolim-Colombo, Fernanda M, Lorenzi-Filho, Geraldo |
| Zdroj: |
Journal of Clinical Hypertension; Sep2017, Vol. 19 Issue 9, p910-918, 9p |
| Abstrakt: |
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P=.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (β=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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