| Autor: |
Beckett, Emma L, Jones, Patrice, Veysey, Martin, Duesing, Konsta, Martin, Charlotte, Furst, John, Yates, Zoe, Jablonski, Nina G., Chaplin, George, Lucock, Mark |
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| Zdroj: |
American Journal of Human Biology; Sep/Oct2017, Vol. 29 Issue 5, pn/a-N.PAG, 11p |
| Abstrakt: |
Objectives The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects. METHODS Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP. RESULTS Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation ( r2 = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density ( P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased ( P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased ( P = .007 and .04 respectively). Multivariate modelling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation ( R2 = 0.34, P < .0001). CONCLUSIONS Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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