| Autor: |
Lo, Angela Kwok‐Fung, Dawson, Christopher W., Young, Lawrence S., Lo, Kwok‐Wai |
| Zdroj: |
International Journal of Cancer; Oct2017, Vol. 141 Issue 8, p1512-1521, 10p |
| Abstrakt: |
The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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