Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children's Hospital, 2002-2014.
Autor: | Liu, Linlin, Guo, Lingyun, Liu, Yue, Chen, Tianming, Li, Shaoying, Yang, Yonghong, Liu, Gang |
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Předmět: |
BEIJING Children's Hospital (Beijing
China) CRYPTOCOCCOSIS NEUROLOGICAL disorders PROGNOSIS PATIENTS THERAPEUTICS ANTIFUNGAL agents SEIZURES (Medicine) CRYPTOCOCCUS HEADACHE FUNGAL lung diseases MAGNETIC resonance imaging MYCOSES RESEARCH funding SPASMS CENTRAL nervous system infections TREATMENT effectiveness RETROSPECTIVE studies DIAGNOSIS |
Zdroj: | European Journal of Pediatrics; Sep2017, Vol. 176 Issue 9, p1235-1244, 10p, 1 Black and White Photograph, 5 Charts, 1 Graph, 1 Map |
Abstrakt: | Cryptococcosis is a rare pediatric disease. The aim of the study is to describe clinical characteristics and prognosis of pediatric cryptococcosis from 2002 to 2014 in Beijing Children's Hospital. A total of 53 cases of cryptococcosis were identified, 69.8% of which were males. The mean age was 7 years. Forty-one (77.4%) patients had no underlying conditions. Fever, headache, and vomiting were the most common symptoms. The most common sites were the central nervous system (CNS), followed by the lungs. Most patients received a combination of amphotericin B and fluconazole with or without flucytosine as their initial regimen. Twenty-seven patients received a follow-up and six patients (22.2%) had died. The factors associated with neurological complications or death were headache (P = 0.008), seizures (P = 0.006), visual impairment (P = 0.011), neck stiffness (P = 0.008), low erythrocyte sedimentation rate (ESR) (P = 0.024), and a cerebral spinal fluid (CSF) cryptococcal antigen titer ≥ 1:1024 (P = 0.038). |
Databáze: | Complementary Index |
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