| Autor: |
Sulistio, Adrian, Reyes-Ortega, Felisa, D’Souza, Asha M., Ng, Sarah M. Y., Valade, David, Quinn, John F., Donohue, Andrew C., Mansfeld, Friederike, Blencowe, Anton, Qiao, Greg, Prankerd, Richard, Quirk, Stephen, Whittaker, Michael R., Davis, Thomas P., Tait, Russell J. |
| Zdroj: |
Journal of Materials Chemistry B; 8/21/2017, Vol. 5 Issue 31, p6221-6226, 6p |
| Abstrakt: |
A facile synthesis method of polymer diclofenac conjugates (PDCs) based on biocompatible polyurethane chemistry that provides a high drug loading and offers a high degree of control over diclofenac (DCF) release kinetics is described. DCF incorporating monomer was reacted with ethyl-l-lysine diisocyanate (ELDI) and different amounts of polyethylene glycol (PEG) in a one-step synthesis to yield polymers with pendent diclofenac distributed along the backbone. By adjusting the co-monomers feed ratio, the drug loading could be tailored accordingly to give DCF loading of up to 38 w/w%. The release rate could also be controlled easily by changing the amount of PEG in the backbone. Above 10 w/w% of PEG, the in vitro DCF release studies in physiological conditions showed an apparent zero-order profile without an initial burst effect for up to 120 days. The PDCs described may be suitable for long-term intra-articular (IA) delivery for the treatment of osteoarthritis (OA). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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