Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.

Autor: Bonora, Enzo, Targher, Giovanni, Alberiche, Maria, Bonadonna, Riccardo C., Saggiani, Francesca, Zenere, Marina B., Monauni, Tiziano, Muggeo, Michele, Bonora, E, Targher, G, Alberiche, M, Bonadonna, R C, Saggiani, F, Zenere, M B, Monauni, T, Muggeo, M
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Zdroj: Diabetes Care; Jan2000, Vol. 23 Issue 1, p57-63, 7p, 2 Charts, 2 Graphs
Abstrakt: Objective: To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.Research Design and Methods: In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity.Results: We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P<0.0001), with no substantial differences between men (r = -0.800) and women (r = -0.796), younger (aged <50 years, r = -0.832) and older (r = -0.800) subjects, nonobese (BMI <27 kg/m2, r = -0.800) and obese (r = -0.765) subjects, nondiabetic (r = -0.754) and diabetic (r = -0.695) subjects, and normotensive ( r = -0.786) and hypertensive (r = -0.762) subjects. Also, we found good agreement between the two methods in the categorization of subjects according to insulin sensitivity (weighted k = 0.63).Conclusions: We conclude that the HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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