| Autor: |
Feng Zhu, Tianyi Yang, Walczak, Maciej A. |
| Předmět: |
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| Zdroj: |
Synlett; 2017, Vol. 28 Issue 13, p1510-1516, 7p |
| Abstrakt: |
Aryl C-glycosides are common structural motifs found in bioactive natural products and commercially available drugs. Despite their importance, most chemical methods to prepare C-glycosides have relied on the nucleophilic addition/substitution of a glycosyl electrophile, which result in variable anomeric selectivities and yields. Furthermore, these methods are not compatible with saccharides containing free hydroxyl groups. Here, we describe a direct cross-coupling reaction of anomeric nucleophiles (anomeric stannanes) and aryl halides. This method is the first general approach to the synthesis of aryl C-glycosides resulting in exclusive anomeric selectivities for both anomers for a broad range of aryl and carbohydrate coupling partners (including unprotected saccharides). 1 Introduction 2 Synthesis of Anomeric Stannanes 3 Glycosyl Stille Cross-Coupling 4 Future Outlook 5 Summary [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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